diff --git a/libs/partners/anthropic/tests/conftest.py b/libs/partners/anthropic/tests/conftest.py
index 26d854f671..0a7e2b83a7 100644
--- a/libs/partners/anthropic/tests/conftest.py
+++ b/libs/partners/anthropic/tests/conftest.py
@@ -1,9 +1,54 @@
+from collections.abc import Iterator
 from typing import Any
 
+import httpx
 import pytest
 from langchain_tests.conftest import CustomPersister, CustomSerializer, base_vcr_config
 from vcr import VCR  # type: ignore[import-untyped]
 
+# Pristine, unpatched httpx transport handlers captured at import time (before
+# any cassette is installed). VCR monkeypatches these while a cassette is
+# active and restores them on teardown -- unless saving the cassette raises,
+# in which case `vcr.cassette.CassetteContextDecorator.__exit__` skips its
+# un-patch step and leaves the transport patched. That leak then intercepts
+# every later request in the same worker (e.g. live integration tests get a
+# stale cassette and fail with confusing connection errors).
+_PRISTINE_HTTPX_TRANSPORTS = {
+    (httpx.HTTPTransport, "handle_request"): httpx.HTTPTransport.handle_request,
+    (
+        httpx.AsyncHTTPTransport,
+        "handle_async_request",
+    ): httpx.AsyncHTTPTransport.handle_async_request,
+}
+
+
+def _restore_httpx_transports() -> None:
+    """Undo any VCR monkeypatching left behind on httpx transports."""
+    for (cls, attribute), original in _PRISTINE_HTTPX_TRANSPORTS.items():
+        if getattr(cls, attribute) is not original:
+            setattr(cls, attribute, original)
+
+
+@pytest.fixture(autouse=True)
+def _guard_httpx_transport_patches(
+    request: pytest.FixtureRequest,
+) -> Iterator[None]:
+    """Stop leaked VCR cassette patches from breaking live tests.
+
+    A `@pytest.mark.vcr` test whose cassette fails to save can leave httpx
+    patched for the rest of the worker session. Tests that hit the network
+    (those without a `vcr` marker) then replay against the wrong cassette and
+    fail. Restoring the pristine transports around every non-VCR test keeps
+    such a leak from cascading, without interfering with VCR's own patching
+    during cassette-backed tests.
+    """
+    uses_vcr = request.node.get_closest_marker("vcr") is not None
+    if not uses_vcr:
+        _restore_httpx_transports()
+    yield
+    if not uses_vcr:
+        _restore_httpx_transports()
+
 
 def remove_request_headers(request: Any) -> Any:
     for k in request.headers:
diff --git a/libs/partners/anthropic/tests/unit_tests/test_vcr_patch_leak.py b/libs/partners/anthropic/tests/unit_tests/test_vcr_patch_leak.py
new file mode 100644
index 0000000000..4922f3a1b3
--- /dev/null
+++ b/libs/partners/anthropic/tests/unit_tests/test_vcr_patch_leak.py
@@ -0,0 +1,66 @@
+"""Regression tests for the httpx transport guard in `tests/conftest.py`.
+
+vcrpy leaves httpx patched if saving a cassette raises during teardown, which
+otherwise leaks the patch into unrelated (live) tests running on the same
+worker. The `_restore_httpx_transports` helper and its autouse fixture undo
+that leak so it can't cascade.
+"""
+
+from pathlib import Path
+
+import httpx
+import vcr  # type: ignore[import-untyped]
+from vcr.persisters.filesystem import (  # type: ignore[import-untyped]
+    CassetteNotFoundError,
+)
+
+from tests.conftest import _restore_httpx_transports
+
+
+class _BoomPersister:
+    """Persister that fails to load and errors while saving a cassette."""
+
+    @staticmethod
+    def load_cassette(*_args: object, **_kwargs: object) -> tuple[list, list]:
+        raise CassetteNotFoundError
+
+    @staticmethod
+    def save_cassette(*_args: object, **_kwargs: object) -> None:
+        msg = "serialization boom"
+        raise RuntimeError(msg)
+
+
+def _ok_response(_request: httpx.Request) -> httpx.Response:
+    return httpx.Response(200, text="ok")
+
+
+def test_restore_httpx_transports_is_a_noop_when_unpatched() -> None:
+    original = httpx.HTTPTransport.handle_request
+    _restore_httpx_transports()
+    assert httpx.HTTPTransport.handle_request is original
+
+
+def test_restore_httpx_transports_reverts_leaked_vcr_patch(tmp_path: Path) -> None:
+    original_sync = httpx.HTTPTransport.handle_request
+    original_async = httpx.AsyncHTTPTransport.handle_async_request
+
+    my_vcr = vcr.VCR(record_mode="once")
+    my_vcr.register_persister(_BoomPersister())
+
+    # Recording a new interaction makes the cassette dirty; the failing save
+    # then trips the vcrpy bug that skips un-patching httpx on teardown.
+    try:
+        with my_vcr.use_cassette(str(tmp_path / "leak.yaml")):
+            transport = httpx.MockTransport(_ok_response)
+            with httpx.Client(transport=transport) as client:
+                client.get("http://example.test/")
+    except RuntimeError:
+        pass
+
+    # The leak is real: httpx is still patched by VCR.
+    assert httpx.HTTPTransport.handle_request is not original_sync
+
+    _restore_httpx_transports()
+
+    assert httpx.HTTPTransport.handle_request is original_sync
+    assert httpx.AsyncHTTPTransport.handle_async_request is original_async